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Oral corticosteroids (long-term use) Common side effects of long-term use of oral steroid medicines include: Osteoporosis (loss of bone)Gynecomastia (male breast enlargement) Bruxism or jaundice (swelling) Pimples and pimples common side effects of short-term usage: Hair loss Skin darkening (pigmentation) Pimple deposits Skin ulcerations Hair fall out Pain and tenderness around the mouth Nervousness Dogs (and most cats) who received systemic corticosteroids may react, especially to new vaccines. Dogs (and most cats) are more susceptible to side effects of systemic corticosteroids because systemic corticosteroids cause blood cell death, and the body's immune system does not function as well when the body is inflamed. Corticosteroids can be used with food. Corticosteroids are a medication used to promote healthy growth or to heal painful wound. You can use steroids (long-term use) to treat many skin problems and other conditions such as: Arthritis Fatigue Rashes (especially in young adults, who are more likely to suffer from rash) Skin infections Hearing loss Skin problems Colds Eczema Skin diseases Skin tumors Swelling Follicular hyperplasia (red, bumpy, and inflamed skin) Skin cancer Diabetes (kidney complications) Heart problems High blood pressure High blood sugar High cholesterol High blood pressure can increase the risk of developing a heart attack, stroke or other cardiovascular problems. In some cases, it may be necessary to dial 911 in some instances when heart attack or stroke symptoms emerge during treatment with a corticosteroid. You may need to use a pacemaker (a pacemaker is medical equipment) or a breathing tube to keep your heart beating. Side effects of long-term use of oral steroids should not interfere with your pet's ability to work or to play safely.